B7 family members and their receptors play key roles in regulating T cell responses, and constitute very attractive targets for developing immunotherapeutic drugs.V-Set and Immunoglobulin domain containing 3 (VSIG3), a ligand for the novel B7 family immune checkpoint V-domain immunoglobulin suppressor of T cell activation (VISTA), can significantly
ESPL1/Separase, an endopeptidase, is required for centrosome duplication and separation of sister-chromatides in Steamrollers anaphase of mitosis.Overexpression and deregulated proteolytic activity of Separase as frequently observed in human cancers is associated with the occurrence of supernumerary centrosomes, chromosomal missegregation and aneup
The article is a résumé of Mariusz Grzegorzek’s work.We are presented with sensory play detailed descriptions of the tricks and techniques applied in each of his movies: his first short film Krakatau, The Conversation with a Man from the Closet, The Queen of Angels, and I Am Yours.The author points to the director’s inspirations and the rise
The way we talk about complex and abstract ideas is suffused with metaphor.In five experiments, we explore how these metaphors influence the way that we reason about complex issues and forage for further information about them.We find that even the subtlest instantiation of a metaphor (via a single word) Puzzle can have a powerful influence over ho
Kai Zhang, Yongtai Zhang, Zhe Li, Nana Li, Nianping Feng Department of Pharmaceutical Sciences, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China Abstract: In this study, a novel glycerosome copyright containing essential oils was prepared for topical administration of paeoniflorin (